John Romero explores the evolving role of artificial intelligence in game development. He highlights AI's potential for enhancing gameplay, such as creating dynamic and responsive environments when its custom crafted by the team. However, he cautions against over-reliance on AI for creative decisions, emphasizing that human creativity and intuition remain irreplaceable. Romero also discusses ethical considerations, urging developers to use AI responsibly to avoid negative impacts on player experience and industry practices​.